Senior Lecturer · University of Edinburgh

Luke
McNally

Modelling complex systems — from cognition and microbial ecology to AI safety and coordination.

School of Biological Sciences · King’s Buildings, Edinburgh
Logistic mountains illustration

Modelling complex
systems

I’m a Senior Lecturer in the School of Biological Sciences at the University of Edinburgh. The common thread across my work is modelling complex systems — using game theory, neural networks, phylogenetics, and computational approaches to understand how interactions between agents produce system-level outcomes.

I started with human and primate cognition, asking how cooperation, deception and cognition co-evolved. I moved into microbial dynamics — social interactions, community ecology, antimicrobial resistance. Now I work primarily on AI safety, applying evolutionary game theory to predict the behaviour of powerful AI systems and to study coordination mechanisms for AI governance.

Research
areas

My research uses computational and mathematical models to study complex systems. The connecting thread is understanding how interactions between agents — whether neurons, microbes, or AI systems — produce emergent dynamics at the system level.

01 —
Cognition & Social Behaviour

How did cooperation, deception and cognition co-evolve in humans and primates? Using neural networks, game theory and phylogenetic analyses to model the evolutionary dynamics of social intelligence.

neural networksgame theory phylogeneticssocial evolution
02 —
Microbial Dynamics & Epidemiology

Modelling social interactions in microbial communities, gut microbiome dynamics, and antimicrobial resistance. Includes work on the Global Sewage Surveillance Project and machine learning approaches to predicting how AMR burden changes with population demographics.

AMRmicrobiome sewage surveillancemachine learning
03 —
AI Safety & Coordination

Applying evolutionary game theory to predict the behaviour of powerful AI systems and to study coordination mechanisms that could slow unsafe AI development. Also designing experiments to study AI cooperation and deception, and developing benchmarks for AI research prediction.

evolutionary game theoryAI alignment existential riskcoordination
04 —
AI for Evidence-Based Policy

As Resident Data Scientist at Nesta, developed AI-powered tools for evidence synthesis in policymaking — using NLP, large language models and complex systems modelling to help policymakers navigate evidence about which interventions work, with a focus on early-years outcomes.

evidence synthesisNLP policyLLMs
↗ Google Scholar — Full Publication Record

Teaching
& outreach

I teach across ecology, evolution, microbial genomics and AI tools for researchers. I also run public engagement activities through the Edinburgh Science Festival.

  • BILG10 / BILG11 Applied Ecology & Evolution From theory to field — quantitative approaches to population biology, natural selection, and ecological dynamics.
  • Molecular Microbiology Microbial Genomics & Bioinformatics Sequencing, annotation, phylogenetics — the practical toolkit of modern microbiology.
  • AI Training Generative AI for Biology 4-hour intensive workshops for PhD students and early-career researchers on working critically and effectively with large language models.
  • Edinburgh Science Festival Coordination & Complexity Activity-based learning for primary school children on Goodhart’s Law, tragedy of the commons, and why good intentions aren’t enough.
  • PhD Supervision Graduate Research Mentoring Supervising PhD students and undergraduate projects across evolutionary biology, microbial ecology, and bioinformatics.

AI safety
& policy

I think AI development poses serious existential risks that current policy doesn’t adequately address. Alongside my research, I work on AI governance advocacy and train others to engage with policymakers on these issues.

Game theory — particularly evolutionary game theory — provides useful tools for thinking about coordination failures in AI development: situations where uncoordinated competition between actors produces outcomes none of them wanted. I apply these frameworks both in research and in policy engagement.

“Uncoordinated competition producing outcomes no actor wanted is a well-studied failure mode in evolutionary biology. It’s also a reasonable description of the current AI development landscape.”
— On coordination failures in AI development
Torchbearer Community Trainer & Coordinator

Training advocates to brief politicians and policymakers on AI existential risk through the Direct Institutional Plan (DIP) programme.

Nesta Resident Data Scientist · 2024–2025

Developed AI-powered tools for evidence synthesis in policymaking, using NLP and complex systems modelling to help policymakers assess which interventions work, with a focus on early-years outcomes.

Career &
education

Luke McNally
Career
2024 – 2025
Resident Data Scientist
Nesta, London, UK
2022 – present
Senior Lecturer
School of Biological Sciences, University of Edinburgh, UK
2017 – 2022
Chancellor’s Fellow
School of Biological Sciences, University of Edinburgh, UK
2015 – 2017
Postdoctoral Research Fellow
Centre for Immunity, Infection and Evolution, University of Edinburgh, UK
2012 – 2015
CIIE Research Fellow
Centre for Immunity, Infection and Evolution, University of Edinburgh, UK
Education
2009 – 2012
PhD in Evolutionary Biology
Trinity College Dublin, Ireland — supervised by Dr. Andrew Jackson
2005 – 2009
B.A. in Zoology (1st Class Honours)
Trinity College Dublin, Ireland

Get in
touch

Happy to hear from researchers, policymakers, journalists, or anyone interested in complex systems, AI safety, or science policy.

luke.mcnally@ed.ac.uk